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David Coyle Selected Research

Hirschsprung Disease (Hirschsprung's Disease)

8/2020Increased protease activated receptors in the colon of patients with Hirschsprung's disease.
11/2019The Extent of the Transition Zone in Hirschsprung Disease.
9/2019Altered expression of caveolin-1 in the colon of patients with Hirschsprung's disease.
1/2019Altered expression of inflammasomes in Hirschsprung's disease.
3/2018Reduction of hydrogen sulfide synthesis enzymes cystathionine-β-synthase and cystathionine-γ-lyase in the colon of patients with Hirschsprungs disease.
11/2016Altered expression of a two-pore domain (K2P) mechano-gated potassium channel TREK-1 in Hirschsprung's disease.
11/2016Expression of connexin 26 and connexin 43 is reduced in Hirschsprung's disease.
6/2016Altered expression of ATP-sensitive K(+) channels in Hirschsprung's disease.
5/2016Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease.
3/2016Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon.
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David Coyle Research Topics

Disease

14Hirschsprung Disease (Hirschsprung's Disease)
08/2020 - 05/2015
8Imperforate Anus
09/2019 - 05/2015
6Anorectal Malformations
11/2019 - 11/2015
3Inflammation (Inflammations)
09/2019 - 09/2016
2Colitis
01/2019 - 06/2016
2Infections
01/2019 - 01/2017
2Intellectual Disability (Idiocy)
11/2018 - 08/2017
2Enterocolitis
11/2016 - 05/2016
1Ganglion Cysts (Ganglion)
11/2019
1Anuria
04/2017
1Urinary Tract Infections (Urinary Tract Infection)
01/2017
1Pathologic Processes
11/2016
1Dysgerminoma
10/2016
1Neoplasms (Cancer)
10/2016
1Gonadoblastoma
10/2016
1Pain (Aches)
09/2016
1Congenital Diaphragmatic Hernias
04/2016
1Vomiting
06/2015
1Urinary Retention
04/2015
1Pheochromocytoma
05/2011
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
05/2011

Drug/Important Bio-Agent (IBA)

3Proteins (Proteins, Gene)FDA Link
08/2020 - 05/2015
1Proteinase-Activated ReceptorsIBA
08/2020
1Caveolin 1IBA
09/2019
1Protein Isoforms (Isoforms)IBA
09/2019
1Nitric Oxide Synthase (NO Synthase)IBA
09/2019
1Multiprotein ComplexesIBA
01/2019
1InflammasomesIBA
01/2019
1LyasesIBA
03/2018
1CystathionineIBA
03/2018
1Cysteine (L-Cysteine)FDA Link
03/2018
1EnzymesIBA
03/2018
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
03/2018
1Anti-Bacterial Agents (Antibiotics)IBA
01/2017
1Anti-Infective Agents (Microbicides)IBA
01/2017
1Connexin 43 (Connexin43)IBA
11/2016
1Potassium Channels (Potassium Channel)IBA
11/2016
1potassium channel protein TREK-1IBA
11/2016
1Connexin 26IBA
11/2016
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2016
1Voltage-Gated Sodium ChannelsIBA
09/2016
1Adenosine Triphosphate (ATP)IBA
06/2016
1Biomarkers (Surrogate Marker)IBA
05/2016
1Serotonin (5 Hydroxytryptamine)IBA
05/2016
1Tryptophan (L-Tryptophan)FDA Link
05/2016
1Tryptophan HydroxylaseIBA
05/2016
1Neurotransmitter Agents (Neurotransmitter)IBA
05/2016
1RetinoidsIBA
04/2016
1Tretinoin (Retinoic Acid)FDA LinkGeneric
04/2016
1Vitamin A (Retinol)FDA LinkGeneric
04/2016
1Retinol-Binding Proteins (Retinoid Binding Proteins)IBA
04/2016
1nitrofenIBA
04/2016
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
03/2016
1Anoctamin-1IBA
02/2016
1rho-Associated KinasesIBA
11/2015
1Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)IBA
10/2015
1Cyclic Nucleotide-Gated Cation ChannelsIBA
05/2015
1NucleotidesIBA
05/2015
1polyoxyethyleneamineIBA
04/2015
1Propranolol (Inderal)FDA LinkGeneric
05/2011

Therapy/Procedure

14Colostomy
11/2019 - 05/2015
2Therapeutics
11/2018 - 08/2017
1Transplantation
04/2017
1Castration
10/2016
1Gastrostomy
06/2015
1Epidural Analgesia
04/2015
1Urinary Catheters
04/2015